Levofloksatsin – keng ta’sir doirasiga ega sintetik ftorxinolon.
DNK-giraza (topoizomeraza II) va topoizomeraza IV ni ingibitsiya qiladi, DNK superspiralizatsiyasini va DNK zanjiri uzilishini tikilishini buzadi, DNK sintezini susaytiradi, sezgir mikroorganizmlarning tsitoplazmasi, xujayra devori va membranalarida chuqur morfologik o‘zgarishlarni chaqiradi.
Levofloksatsin mikroorganizmlarning quyidagi shtammlariga nisbatan faol:
Aerob grammusbat mikroorganizmlar:
Corynebacterium diphtheriae, Enterococcus spp.
(shu jumladan Enterococcus faecalis), Listeria monocytogenes, Staphylococcus spp.
(leykotoksin saqlovchi va koagulaza manfiy metitsillinga sezgir / o‘rtacha sezgir shtammlari, shu jumladan Staphylococcus aureus, Staphylococcus epidermidis ning metitsillinga sezgir shtammlari), Streptococcus spp.
(shu jumladan Streptococcus ning C va G guruhi shtammlari, Streptococcus agallactiae, Streptococcus pyogenes, Streptococcus pneumoniae ning penitsillinga sezgir / o‘rtacha sezgir / rezistent shtammlari, Streptococcus viridans guruhining penitsillinga sezgir / rezistent shtammlari)
Aerob grammanfiy mikroorganizmlar:
Acinetobacter spp.
(shu jumladan Acinetobacter baumannil), Actinobacillus actinomycetemcomitans, Citrobacter freundii, Eikenella corrodens, Enterobacter spp.
(shu jumladan Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter cloacae), Escherichia coli, Gardnerella vaginalis, Haemophilus spp.
(shu jumladan Haemophilus ducreyi, Haemophilus parainfluenzae, Haemophilus influenzae ning ampitsillinga sezgir / rezistent shtammlari), Helicobacter pylori, Klebsiella spp (shu jumladan Klebsiella oxytaca, Klebsiella pneumoniae), Moraxela catarrhalis (b-laktamazani ishlab chiqaradigan va ishlab chiqarmaydigan shtammlari), Morganella morganii, Neisseria spp.
(shu jumladan Neisseria meningitides va Neisseria gonorroeae ning penitsillinazani ishlab chiqaradigan va ishlab chiqarmaydigan shtammlari), Pasteurella spp (shu jumladan Pasteurella conis, Pasreurella dagmatis, Pasteurella multocida), Proteus mirabilis, Proteus vulgaris, Providencia spp.
(shu jumladan Providencia rettgeri, Providencia stuartii), Pseudomonas spp.
(shu jumladan Pseudomonas aeruginosa), Serratia spp.
(shu jumladan Serratia marcescens), Salmonella spp.
Anaerob mikroorganizmlar:
Bacteroides fragilis, Bifidobacterium spp., Clostridium perfringens, Fusobacterium spp., Peptostreptococcus, Propionibacterum spp., Veilonella spp.;
Boshqa mikroorganizmlar:
Bartonella spp., Chlamydia spp.
(shu jumladan Chlamydia pneumaniae, Chlamydia psittaci, Chlamydia trachomatis, Legionella pneumophila), Mycobacterium spp.
(shu jumladan Mycobacterium leprae, Micopbacterium tuberculosis), Mycoplasma spp.
(shu jumladan Mycoplasma hominis, Mycoplasma pneumoniae), Ricketsia spp., Ureaplasma urealyticum.
Quyidagi mikroorganizmlar preparatga chidamli:
Aerob grammusbat mikroorganizmlar:
Corynebacterium jeikeium, Staphylococcus spp.
(koagulaza manfiy metitsillinga rezistent shtammlari, shu jumladan Staphylococcus aureus ning metitsillinga rezistent shtammlari).
Aerob grammanfiy mikroorganizmlar: Alcaligenes xylosoxidans.
Boshqa mikroorganizmlar: Mycobacterium avium.