Keng ta’sir doirasiga ega antibiotik.
Makrolid antibiotiklar – azalidlar kichik guruhi vakili hisoblanadi.
Yallig‘lanish o‘chog‘ida yuqori kontentratsiyalari hosil qilinganida bakteritsid ta’sir ko‘rsatadi.
Azitromitsinning ta’sir mexanizmi mikrob xujayralarining oqsillari sintezini susaytirishi bilan bog‘liq.
Ribosomaning 50S subbirligi bilan bog‘lanib, peptidtranslokazani translyatsiya bosqichida susaytiradi, oqsil sintezini bostiradi, bakteriyalarni rivojlanishini va o‘sishini sekinlashtiradi.
Qator grammusbat, grammanfiy, anaerob, xujayra ichki va boshqa qator mikroorganizmlarga nisbatan faollikka ega.
Azitromitsinga grammusbat kokklar: Streptococcus pneumoniae, St.
pygones, St.
agalactiae, C, F va G guruhi streptokokklari, Staphylococcus aureus, St.
viridans; grammanfiy bakteriyalar: Haemophilus influenzae, Moraxella catarrhalis, Bordetella pertussis, B.
parapertusis, Legionella pneumophila, H.ducrei, Campylobacter jejuni, Neisseria gonorrhoeae va Gardnerella vaginalis; ba’zi anaerob mikroorganizmlar: Bacteroides bivius, Clostridium perfringens, Peptostreptococcus spp; va shuningdek Chlamydiatrachomatis, Mycoplasma pneumoniae, Ureaplasma urealyticum, Treponema pallidum, Borrelia burgdoferi sezgir.
Azitromitsinning minimal bostiruvchi kontentratsiyalari (MBK).
MVK90 (mkg/ml) Mikroorganizmlar
MVK90 (mkg/ml) Mikroorganizmlar
MVK90 ≤0,01 mkg/ml Haemophilus ducreyi, Mycoplasma pneumoniae
MVK90 0,01-0,1 mkg/ml Actinomyces species, Bordetella pertussis, Bordetella burgdorferi, Gardnerella virginalis, Mobiluncus species, Moraxella catarrhalis,
Propionibacterium acnes
MVK90 0,01-2,0 mkg/ml Bacteriodes bivius, Bordetella parapertussis, Brucella melitensis, Campylobacter jejuni, Clostridium perfringens, Fusobacterium
necrophorum, Haemophilus infl uenzae, Haemophilus parainfl uenzae, Helicobacter pylori, Chlamydia pneumoniae, Chlamydia
trachomatis, Legionella pneumophila, Listeria monocytogenes, Neisseria gonorrhoeae, Neisseria meningitidis, Pasteurella haemolytica,
Pasteurella multocida, Peptococcus species, Peptostreptococcus, Plesiomonas shigelloides, Staphylococcus aureus, Streptococcus
agalactiae, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans, Streptococcus
gruppalari C, F, G, Ureaplasma urealyticum, Vibrio cholerae, Vibrio parahaemolyticus
MVK90 2,0-8,0 mkg/ml Acinetobacter calcoaceticus, Aeromonas hydrophylia, Bacteroides fragilis, Bacteroides oralis, Clostridium diffi cile, Escherichia coli,
Eubacterium lentum, Fusobacterium nucleatum, Salmonella enteritidis, Salmonella typhi, Shigella sonnei, Yersinia enterocolitica
MVK90 >10 mkg/ml Citrobacter species, Corynebacterium species, Enterobacter aerogenes, Enterobacter cloacae, Enterococcus faecalis, Enterococcus
faecium, Eubacterium limosum, Klebsiella pneumoniae, Klebsiella oxytoca, Mycoplasma hominis, Proteus species, Pseudomonas
aeruginosa, Serratia marcescen