Ta’sir etuvchi modda(XPN):
Sefoperazon + [Sulbaktam] (Cefoperazon + [Sulbaktam]),
Farmakalogik guruhi:
Kombinatsiyalangan preparat. Cefoperazone — uchinchi avlod sefalosporin antibiotiklari, bakteritsid ta’sir qiladi, keng ta’sir doirasiga ega; grammusbat va grammusbat mikroorganizmlarning beta-laktamazalariga chidamli aerob va anaerob grammusbat va grammusbat mikroorganizmlarga (shu jumladan Pseudomonas aeruginosa) qarshi juda faol.
Sulbaktam — beta-laktam antibiotiklariga chidamli mikroorganizmlar tomonidan chiqariladigan beta-laktamazalarning qaytarilmas inhibitori; penitsillinlar va sefalosporinlarni chidamli mikroorganizmlarning beta-laktamazalari bilan yo’q qilinishini oldini oladi; penitsillin bilan bog’langan oqsillar bilan bog’lanib, penitsillinlar va sefalosporinlar bilan bir vaqtda qo’llanganda sinergizmni namoyon qiladi.
Sulbaktam va sefoperazon birikmasi sefoperazonga sezgir bo’lgan barcha mikroorganizmlarga qarshi ta’sir ko’rsatadi va sinergik ta’sir ko’rsatadi (har bir komponent uchun qiymatlarga nisbatan kombinatsiyaning MIK-ni 4 baravargacha kamaytiradi) mikroorganizmlarga qarshi: Haemophilus influenzae, Bacteroides spp., Staphylococcus spp. calcoaceticus, Enterobacter aerogenes, Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Morganella morganii, Citrobacter freundii, Enterobacter cloacae, Citrobacter diversus.
Bu mikroorganizmlarning keng spektriga qarshi in vitro faoldir: grammusbat bakteriyalar — Staphylococcus aureus (shu jumladan penitsillinaza hosil qiluvchi va hosil qilmaydigan shtammlar), Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes (A guruhining beta-gemolitik shtammlari), — B guruhidagi gemolitik shtamm), ko’pchilik beta-gemolitik Streptococcus spp., Enterococcus faecalis;
grammusbat bakteriyalar — Escherichia coli, Klebsiella spp., Enterobacter spp., Citrobacter spp., Haemophilus influenzae, Proteus mirabilis, Morganella morganii, Providencia rettgeri, Providencia spp., Serratia spp. (shu jumladan Serratia marcescens), Salmonella spp., Shigella spp., Pseudomonas aeruginosa, Acinetobacter calcoaceticus, Neisseria gonorrhoeae, Neisseria meningitidis; Bordetella pertussis, Yersinia enterocolitica; anaerob bakteriyalar — Bacteroides fragilis, Fusobacterium spp., Peptococcus spp., Peptostreptococcus spp., Veillonella spp., Clostridium spp., Eubacterium spp., Lactobacillus spp.